Overview
SCIENTIFIC SCORE
Questionable
Based on 12 Researches
6.3
USERS' SCORE
Medium or Average
Based on 25 Reviews
6.3
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Vitamin C (from culture of S. cerevisiae)
25 mg
28%
Folate (from culture of S. cerevisiae)
400 mcg DFE
100%
Vitamin B12 (as Methylcobalamin from culture of S. cerevisiae)
500 mcg
20833%
Iron (from Brown Rice Chelate)
22 mg
122%
RAW Organic Fruit & Vegetable BlendOrganic Apple (fruit), Organic Beet (root), Organic Broccoli (stalk & flower), Organic Carrot (root), Organic Spinach (leaf), Organic Tomato (fruit), Organic Strawberry (fruit), Organic Tart Cherry (fruit), Organic Blackberry (fruit), Organic Green Bell Pepper (fruit), Organic Brussels Sprout (leaf), Organic Blueberry (fruit), Organic Ginger (root), Organic Garlic (bulb), Organic Green Onion (bulb), Organic Raspberry (fruit), Organic Parsley (leaf), Organic Cauliflower (flower & stem), Organic Red Cabbage (leaf), Organic Kale (leaf), Organic Cucumber (gourd), Organic Celery (stalk), Organic Asparagus Juice (flower & stem)
310 mg
+
RAW Probiotic & Enzyme BlendLipase, Protease, Aspergillopepsin, beta-Glucanase, Cellulase, Bromelain, Phytase, Lactase, Papain, Peptidase, Pectinase, Hemicellulase, Xylanase, [Lactobacillus plantarum, Lactobacillus bulgaricus] (500 Million CFU)
60 mg
+
Top Medical Research Studies
0
Vitamin B12 ineffective for CFS
We explored the effectiveness of high-dose vitamin B12 injections on chronic fatigue syndrome (CFS) through two case reports that utilized N of 1 trials. This approach allowed us to make tailored treatment decisions based on individual responses to the therapy.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
Read More
9
We aimed to explore the effects of folinic acid, also known as leucovorin, on patients suffering from chronic fatigue syndrome (CFS). Our investigation revealed some fascinating findings about this often misunderstood condition, particularly the links to immune response and Epstein-Barr virus (EBV) infection.
In our evaluation of 58 CFS patients, we discovered that nearly all had previously been exposed to EBV, with a striking 72% showing signs of active reactivation. Additionally, an overwhelming 94% were found to have a severe B-cell immunodeficiency, evidenced by a marked reduction in their CD19+IgM+ mature B-lymphocyte population.
What stood out was that after treatment with folinic acid, an impressive 81% of the participants reported experiencing a noticeable improvement in their symptoms. This suggests that folinic acid might play a significant role in the management of CFS, particularly for those struggling with related immune deficiencies and EBV responses.
Our findings bring new insights into CFS, indicating that it may be a condition responding well to folinic acid treatment. This opens up exciting avenues for further research into effective therapies for those affected by this challenging syndrome.
In our evaluation of 58 CFS patients, we discovered that nearly all had previously been exposed to EBV, with a striking 72% showing signs of active reactivation. Additionally, an overwhelming 94% were found to have a severe B-cell immunodeficiency, evidenced by a marked reduction in their CD19+IgM+ mature B-lymphocyte population.
What stood out was that after treatment with folinic acid, an impressive 81% of the participants reported experiencing a noticeable improvement in their symptoms. This suggests that folinic acid might play a significant role in the management of CFS, particularly for those struggling with related immune deficiencies and EBV responses.
Our findings bring new insights into CFS, indicating that it may be a condition responding well to folinic acid treatment. This opens up exciting avenues for further research into effective therapies for those affected by this challenging syndrome.
Read More
8
Folate improves fatigue-related disorders
We examined two groups of patients who exhibited neurological and psychiatric disorders responsive to folic acid treatment. The first group of seven individuals suffered from an acquired folate deficiency due to either poor absorption of nutrients or an inadequate diet. Their symptoms included significant fatigue, weight loss, and various neurological impairments. The second group, consisting of nine patients, presented idiopathic folate deficiency with chronic fatigue and family histories of restless legs syndrome.
Through neuropsychological testing, we observed abnormal intellectual functioning in all patients, along with issues highlighted on imaging studies like computerized transaxial tomography. Remarkably, after 6 to 12 months of folic acid therapy, a substantial improvement in their cognitive abilities and overall functioning was recorded.
This suggests that addressing folate deficiency might alleviate some aspects of fatigue and cognitive decline commonly associated with chronic fatigue syndrome. Our findings imply that long-term folate supplementation may lead to positive changes in those struggling with fatigue-related conditions, although the label of chronic fatigue syndrome was not explicitly used.
Through neuropsychological testing, we observed abnormal intellectual functioning in all patients, along with issues highlighted on imaging studies like computerized transaxial tomography. Remarkably, after 6 to 12 months of folic acid therapy, a substantial improvement in their cognitive abilities and overall functioning was recorded.
This suggests that addressing folate deficiency might alleviate some aspects of fatigue and cognitive decline commonly associated with chronic fatigue syndrome. Our findings imply that long-term folate supplementation may lead to positive changes in those struggling with fatigue-related conditions, although the label of chronic fatigue syndrome was not explicitly used.
Read More
Most Useful Reviews
0
Negative reaction
44 people found this helpful
Unfortunately, this was an unsuccessful purchase for my chronic fatigue syndrome. While I was relieved there was no constipation, I experienced excitability and palpitations, which I believe were due to the excessive vitamin B12 dosage. It's crucial to be aware of what I’m consuming.
Read More
9
Reduced fatigue
3 people found this helpful
This complex is remarkable! It not only provides iron but also includes vitamin B12, vitamin C, and probiotics that enhance absorption. I noticed a significant reduction in chronic fatigue syndrome symptoms, with improved mood and energy levels. By the end of the course, my blood tests showed a considerable recovery in iron levels.
Read More
9
Quick results
3 people found this helpful
I'm thrilled with the quick improvement in my health! After struggling with chronic fatigue syndrome and low ferritin levels, I felt a noticeable change by the third day of taking this product. Within a week, my symptoms disappeared, prompting me to order more. Highly recommend!
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 12 Researches
6.3
- All Researches
9
We aimed to explore the effects of folinic acid, also known as leucovorin, on patients suffering from chronic fatigue syndrome (CFS). Our investigation revealed some fascinating findings about this often misunderstood condition, particularly the links to immune response and Epstein-Barr virus (EBV) infection.
In our evaluation of 58 CFS patients, we discovered that nearly all had previously been exposed to EBV, with a striking 72% showing signs of active reactivation. Additionally, an overwhelming 94% were found to have a severe B-cell immunodeficiency, evidenced by a marked reduction in their CD19+IgM+ mature B-lymphocyte population.
What stood out was that after treatment with folinic acid, an impressive 81% of the participants reported experiencing a noticeable improvement in their symptoms. This suggests that folinic acid might play a significant role in the management of CFS, particularly for those struggling with related immune deficiencies and EBV responses.
Our findings bring new insights into CFS, indicating that it may be a condition responding well to folinic acid treatment. This opens up exciting avenues for further research into effective therapies for those affected by this challenging syndrome.
In our evaluation of 58 CFS patients, we discovered that nearly all had previously been exposed to EBV, with a striking 72% showing signs of active reactivation. Additionally, an overwhelming 94% were found to have a severe B-cell immunodeficiency, evidenced by a marked reduction in their CD19+IgM+ mature B-lymphocyte population.
What stood out was that after treatment with folinic acid, an impressive 81% of the participants reported experiencing a noticeable improvement in their symptoms. This suggests that folinic acid might play a significant role in the management of CFS, particularly for those struggling with related immune deficiencies and EBV responses.
Our findings bring new insights into CFS, indicating that it may be a condition responding well to folinic acid treatment. This opens up exciting avenues for further research into effective therapies for those affected by this challenging syndrome.
Read More
8
We aimed to evaluate how folic acid, in combination with vitamin B12, impacts individuals with chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME). Our study focused on a group of 38 patients who had received weekly B12 injections for six months to several years.
During our research, we categorized the patients into two groups: Good responders and Mild responders, based on their improvement in symptoms. We found that those who responded positively had received B12 injections more frequently and at higher doses compared to those with lesser improvement. They also tended to use more folic acid daily and were less likely to use strong analgesics.
Our findings suggested a clear relationship between the dosage of B12 and folic acid and the degree of improvement reported by the participants. However, we noted a higher occurrence of fibromyalgia among those with milder responses, indicating that the presence of additional conditions might affect outcomes.
Overall, we observed a dose-response effect suggesting that B12 and folic acid together could bring about meaningful improvements in CFS symptoms. Also, we identified the importance of being aware of possible thyroid issues and highlighted the need for more precise research regarding their interaction with other medications.
During our research, we categorized the patients into two groups: Good responders and Mild responders, based on their improvement in symptoms. We found that those who responded positively had received B12 injections more frequently and at higher doses compared to those with lesser improvement. They also tended to use more folic acid daily and were less likely to use strong analgesics.
Our findings suggested a clear relationship between the dosage of B12 and folic acid and the degree of improvement reported by the participants. However, we noted a higher occurrence of fibromyalgia among those with milder responses, indicating that the presence of additional conditions might affect outcomes.
Overall, we observed a dose-response effect suggesting that B12 and folic acid together could bring about meaningful improvements in CFS symptoms. Also, we identified the importance of being aware of possible thyroid issues and highlighted the need for more precise research regarding their interaction with other medications.
Read More
8
Folate improves fatigue-related disorders
We examined two groups of patients who exhibited neurological and psychiatric disorders responsive to folic acid treatment. The first group of seven individuals suffered from an acquired folate deficiency due to either poor absorption of nutrients or an inadequate diet. Their symptoms included significant fatigue, weight loss, and various neurological impairments. The second group, consisting of nine patients, presented idiopathic folate deficiency with chronic fatigue and family histories of restless legs syndrome.
Through neuropsychological testing, we observed abnormal intellectual functioning in all patients, along with issues highlighted on imaging studies like computerized transaxial tomography. Remarkably, after 6 to 12 months of folic acid therapy, a substantial improvement in their cognitive abilities and overall functioning was recorded.
This suggests that addressing folate deficiency might alleviate some aspects of fatigue and cognitive decline commonly associated with chronic fatigue syndrome. Our findings imply that long-term folate supplementation may lead to positive changes in those struggling with fatigue-related conditions, although the label of chronic fatigue syndrome was not explicitly used.
Through neuropsychological testing, we observed abnormal intellectual functioning in all patients, along with issues highlighted on imaging studies like computerized transaxial tomography. Remarkably, after 6 to 12 months of folic acid therapy, a substantial improvement in their cognitive abilities and overall functioning was recorded.
This suggests that addressing folate deficiency might alleviate some aspects of fatigue and cognitive decline commonly associated with chronic fatigue syndrome. Our findings imply that long-term folate supplementation may lead to positive changes in those struggling with fatigue-related conditions, although the label of chronic fatigue syndrome was not explicitly used.
Read More
8
We examined the impact of vitamin B12 nasal drops on individuals suffering from myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Our study involved fifty-one patients, predominantly female, with an average age of 42 and an average illness duration of 16 years.
After three months of treatment, we measured their vitamin B12 serum levels, physical activity, and fatigue and concentration levels. Interestingly, we found that the participants who responded positively to the treatment experienced significant improvements in their vitamin B12 levels, daily step count, and overall physical activity. Moreover, those who reported a positive response noted a decrease in fatigue levels.
On the flip side, those categorized as non-responders had only a modest increase in vitamin B12 levels, with no notable improvement in other measures. Overall, our findings suggest that nasal drops could serve as a viable alternative to vitamin B12 injections, especially since around two-thirds of participants reported feeling better after treatment. This pilot study opens up new avenues for interventions in managing ME/CFS and highlights the importance of considering alternative treatment methods.
After three months of treatment, we measured their vitamin B12 serum levels, physical activity, and fatigue and concentration levels. Interestingly, we found that the participants who responded positively to the treatment experienced significant improvements in their vitamin B12 levels, daily step count, and overall physical activity. Moreover, those who reported a positive response noted a decrease in fatigue levels.
On the flip side, those categorized as non-responders had only a modest increase in vitamin B12 levels, with no notable improvement in other measures. Overall, our findings suggest that nasal drops could serve as a viable alternative to vitamin B12 injections, especially since around two-thirds of participants reported feeling better after treatment. This pilot study opens up new avenues for interventions in managing ME/CFS and highlights the importance of considering alternative treatment methods.
Read More
8
We recently came across an intriguing study that highlighted the potential benefits of a combination therapy involving lofepramine, L-phenylalanine, and vitamin B12 for patients suffering from multiple sclerosis (MS). Conducted as a randomized, placebo-controlled double-blind trial, the research aimed to evaluate how this combination could help alleviate various symptoms associated with MS and chronic pain.
While this study did address the role of vitamin B12, it was examined alongside lofepramine and phenylalanine. This makes it challenging for us to pinpoint the specific impact of vitamin B12 in the context of chronic fatigue syndrome on its own. The treatment showed effectiveness in improving symptoms within just two to four weeks, but due to the combination of treatments, we need more focused studies to assess vitamin B12's distinct role.
Overall, it's exciting to see a potential link between this therapy and symptom relief, yet we must remain cautious about attributing the benefits solely to vitamin B12, given the blended approach of the therapy used in the trial.
While this study did address the role of vitamin B12, it was examined alongside lofepramine and phenylalanine. This makes it challenging for us to pinpoint the specific impact of vitamin B12 in the context of chronic fatigue syndrome on its own. The treatment showed effectiveness in improving symptoms within just two to four weeks, but due to the combination of treatments, we need more focused studies to assess vitamin B12's distinct role.
Overall, it's exciting to see a potential link between this therapy and symptom relief, yet we must remain cautious about attributing the benefits solely to vitamin B12, given the blended approach of the therapy used in the trial.
Read More
User Reviews
USERS' SCORE
Medium or Average
Based on 25 Reviews
6.3
- All Reviews
- Positive Reviews
- Negative Reviews
0
Negative reaction
44 people found this helpful
Unfortunately, this was an unsuccessful purchase for my chronic fatigue syndrome. While I was relieved there was no constipation, I experienced excitability and palpitations, which I believe were due to the excessive vitamin B12 dosage. It's crucial to be aware of what I’m consuming.
Read More
9
Reduced fatigue
3 people found this helpful
This complex is remarkable! It not only provides iron but also includes vitamin B12, vitamin C, and probiotics that enhance absorption. I noticed a significant reduction in chronic fatigue syndrome symptoms, with improved mood and energy levels. By the end of the course, my blood tests showed a considerable recovery in iron levels.
Read More
9
Quick results
3 people found this helpful
I'm thrilled with the quick improvement in my health! After struggling with chronic fatigue syndrome and low ferritin levels, I felt a noticeable change by the third day of taking this product. Within a week, my symptoms disappeared, prompting me to order more. Highly recommend!
Read More
9
Significant improvement
2 people found this helpful
During the previous pregnancy, my daughter's haemoglobin was low, but this iron supplement, along with another chelated iron, has made a positive impact. Her results are textbook perfect, with no chronic fatigue syndrome or complaints about her stomach.
Read More
0
Severe nausea
2 people found this helpful
It caused me severe nausea and fatigue, which did not suit my chronic fatigue syndrome at all.
Read More
Frequently Asked Questions
9
Quick results
3 people found this helpful
I'm thrilled with the quick improvement in my health! After struggling with chronic fatigue syndrome and low ferritin levels, I felt a noticeable change by the third day of taking this product. Within a week, my symptoms disappeared, prompting me to order more. Highly recommend!
9
Very beneficial
Very good for those suffering from chronic fatigue syndrome who need natural sources of iron that do not cause constipation or stomach discomfort. The aroma and taste are pleasant, and the glass jar is well sealed. I noticed benefits within the first week of use.
9
Reduced fatigue
This is not my first order of this supplement. Having iron deficiency anaemia, I noticed improvements—less hair loss and fading fatigue—after just a month. This convenient product really helps!
0
Severe nausea
2 people found this helpful
It caused me severe nausea and fatigue, which did not suit my chronic fatigue syndrome at all.
2
Stomach issues
I encountered stomach issues with this product, which may vary for others. Unfortunately, it didn’t help my chronic fatigue syndrome and led to fatigue instead.
9
Reduced fatigue
3 people found this helpful
This complex is remarkable! It not only provides iron but also includes vitamin B12, vitamin C, and probiotics that enhance absorption. I noticed a significant reduction in chronic fatigue syndrome symptoms, with improved mood and energy levels. By the end of the course, my blood tests showed a considerable recovery in iron levels.
9
Gentle on stomach
1 people found this helpful
This iron supplement is excellent and gentle on my stomach. Having dealt with chronic fatigue syndrome due to family-related anemia, I found this product to be pain-free and effective, relieving my dizziness and light-headedness from low iron.
0
Negative reaction
44 people found this helpful
Unfortunately, this was an unsuccessful purchase for my chronic fatigue syndrome. While I was relieved there was no constipation, I experienced excitability and palpitations, which I believe were due to the excessive vitamin B12 dosage. It's crucial to be aware of what I’m consuming.
7.5
Improved energy levels
5 people found this helpful
The quality is excellent. I recommend this product for those experiencing chronic fatigue syndrome due to period-related bleeding, but it's important to check for iron deficiency first. This formula is easy to absorb and does not cause constipation. I advise continuing the treatment for three months. There is no discernible taste.
9
Energy boost
The Garden of Life Vitamin Code Raw Iron Vegan Capsules provide a potent source of iron from whole foods to support red blood cell production and combat chronic fatigue syndrome. Enhanced with vitamin C, B12, and probiotics for optimal absorption, this vegan-friendly and gluten-free supplement effectively boosts energy and vitality while alleviating symptoms associated with iron deficiency.
We explored the effects of iron supplementation on individuals suffering from iron deficiency, specifically looking at its impact on symptoms like chronic fatigue syndrome (CFS). This was done through a well-structured study involving 176 blood donors who were iron deficient, with a randomized controlled trial design.
Participants were assigned to receive either intravenous iron or oral iron supplements. Over an 8-12 week period, we assessed changes in symptoms related to iron deficiency, including CFS, restless legs syndrome (RLS), sleeping disorders, and overall quality of life.
The results indicated that iron supplementation may significantly improve the symptoms associated with iron deficiency among blood donors. By addressing the iron deficiency, we noted improvements not only in fatigue but also in wellbeing, confirming that targeted iron treatment can be beneficial for those struggling with chronic fatigue linked to low iron levels. This is an exciting finding for both clinicians and patients, shedding light on a relatively simple intervention that can enhance quality of life.
Participants were assigned to receive either intravenous iron or oral iron supplements. Over an 8-12 week period, we assessed changes in symptoms related to iron deficiency, including CFS, restless legs syndrome (RLS), sleeping disorders, and overall quality of life.
The results indicated that iron supplementation may significantly improve the symptoms associated with iron deficiency among blood donors. By addressing the iron deficiency, we noted improvements not only in fatigue but also in wellbeing, confirming that targeted iron treatment can be beneficial for those struggling with chronic fatigue linked to low iron levels. This is an exciting finding for both clinicians and patients, shedding light on a relatively simple intervention that can enhance quality of life.
9
We aimed to explore the effects of folinic acid, also known as leucovorin, on patients suffering from chronic fatigue syndrome (CFS). Our investigation revealed some fascinating findings about this often misunderstood condition, particularly the links to immune response and Epstein-Barr virus (EBV) infection.
In our evaluation of 58 CFS patients, we discovered that nearly all had previously been exposed to EBV, with a striking 72% showing signs of active reactivation. Additionally, an overwhelming 94% were found to have a severe B-cell immunodeficiency, evidenced by a marked reduction in their CD19+IgM+ mature B-lymphocyte population.
What stood out was that after treatment with folinic acid, an impressive 81% of the participants reported experiencing a noticeable improvement in their symptoms. This suggests that folinic acid might play a significant role in the management of CFS, particularly for those struggling with related immune deficiencies and EBV responses.
Our findings bring new insights into CFS, indicating that it may be a condition responding well to folinic acid treatment. This opens up exciting avenues for further research into effective therapies for those affected by this challenging syndrome.
In our evaluation of 58 CFS patients, we discovered that nearly all had previously been exposed to EBV, with a striking 72% showing signs of active reactivation. Additionally, an overwhelming 94% were found to have a severe B-cell immunodeficiency, evidenced by a marked reduction in their CD19+IgM+ mature B-lymphocyte population.
What stood out was that after treatment with folinic acid, an impressive 81% of the participants reported experiencing a noticeable improvement in their symptoms. This suggests that folinic acid might play a significant role in the management of CFS, particularly for those struggling with related immune deficiencies and EBV responses.
Our findings bring new insights into CFS, indicating that it may be a condition responding well to folinic acid treatment. This opens up exciting avenues for further research into effective therapies for those affected by this challenging syndrome.
8
We aimed to evaluate how folic acid, in combination with vitamin B12, impacts individuals with chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME). Our study focused on a group of 38 patients who had received weekly B12 injections for six months to several years.
During our research, we categorized the patients into two groups: Good responders and Mild responders, based on their improvement in symptoms. We found that those who responded positively had received B12 injections more frequently and at higher doses compared to those with lesser improvement. They also tended to use more folic acid daily and were less likely to use strong analgesics.
Our findings suggested a clear relationship between the dosage of B12 and folic acid and the degree of improvement reported by the participants. However, we noted a higher occurrence of fibromyalgia among those with milder responses, indicating that the presence of additional conditions might affect outcomes.
Overall, we observed a dose-response effect suggesting that B12 and folic acid together could bring about meaningful improvements in CFS symptoms. Also, we identified the importance of being aware of possible thyroid issues and highlighted the need for more precise research regarding their interaction with other medications.
During our research, we categorized the patients into two groups: Good responders and Mild responders, based on their improvement in symptoms. We found that those who responded positively had received B12 injections more frequently and at higher doses compared to those with lesser improvement. They also tended to use more folic acid daily and were less likely to use strong analgesics.
Our findings suggested a clear relationship between the dosage of B12 and folic acid and the degree of improvement reported by the participants. However, we noted a higher occurrence of fibromyalgia among those with milder responses, indicating that the presence of additional conditions might affect outcomes.
Overall, we observed a dose-response effect suggesting that B12 and folic acid together could bring about meaningful improvements in CFS symptoms. Also, we identified the importance of being aware of possible thyroid issues and highlighted the need for more precise research regarding their interaction with other medications.
2
We conducted a carefully designed study to investigate the effects of an injectable treatment combining bovine liver extract, folic acid, and cyanocobalamin on chronic fatigue syndrome (CFS). This involved a double-blind, placebo-controlled crossover trial with 15 patients who met definitive criteria for CFS.
Throughout the study, patients received both the treatment and a placebo in alternating phases. While we observed that both the treatment and placebo seemed to provide some improvement in functional status for the patients, our analysis showed no significant advantage of the liver extract and folic acid combination over the placebo.
This indicates that the response to folate, particularly, is unclear as the placebo effect appeared to be notably strong among participants. Overall, the findings suggest that further research may be needed to ascertain the definitive role of folate in managing chronic fatigue syndrome.
Throughout the study, patients received both the treatment and a placebo in alternating phases. While we observed that both the treatment and placebo seemed to provide some improvement in functional status for the patients, our analysis showed no significant advantage of the liver extract and folic acid combination over the placebo.
This indicates that the response to folate, particularly, is unclear as the placebo effect appeared to be notably strong among participants. Overall, the findings suggest that further research may be needed to ascertain the definitive role of folate in managing chronic fatigue syndrome.
References
- Macher S, Herster C, Holter M, Moritz M, Matzhold EM, et al. The Effect of Parenteral or Oral Iron Supplementation on Fatigue, Sleep, Quality of Life and Restless Legs Syndrome in Iron-Deficient Blood Donors: A Secondary Analysis of the IronWoMan RCT. Nutrients. 2020;12. doi:10.3390/nu12051313
- Regland B, Forsmark S, Halaouate L, Matousek M, Peilot B, et al. Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia. PLoS One. 2015;10:e0124648. doi:10.1371/journal.pone.0124648
- Lundell K, Qazi S, Eddy L, Uckun FM. Clinical activity of folinic acid in patients with chronic fatigue syndrome. Arzneimittelforschung. 2006;56:399.
- Jacobson W, Saich T, Borysiewicz LK, Behan WM, Behan PO, et al. Serum folate and chronic fatigue syndrome. Neurology. 1993;43:2645.
- Kaslow JE, Rucker L, Onishi R. Liver extract-folic acid-cyanocobalamin vs placebo for chronic fatigue syndrome. Arch Intern Med. 1989;149:2501.
- Botez MI, Fontaine F, Botez T, Bachevalier J. Folate-responsive neurological and mental disorders: report of 16 cases. Neuropsychological correlates of computerized transaxial tomography and radionuclide cisternography in folic acid deficiencies. Eur Neurol. 1977;16:230.
- van Campen CLM, Riepma K, Visser FC. Open Trial of Vitamin B12 Nasal Drops in Adults With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Comparison of Responders and Non-Responders. Front Pharmacol. 2019;10:1102. doi:10.3389/fphar.2019.01102
- Loder C, Allawi J, Horrobin DF. Treatment of multiple sclerosis with lofepramine, L-phenylalanine and vitamin B(12): mechanism of action and clinical importance: roles of the locus coeruleus and central noradrenergic systems. Med Hypotheses. 2002;59:594.
- Devitt NF. Chronic fatigue syndrome. JAMA. 1998;279:432.
- Regland B, Andersson M, Abrahamsson L, Bagby J, Dyrehag LE, et al. Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome. Scand J Rheumatol. 1997;26:301.
- Wiebe E. N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports. Can Fam Physician. 1996;42:2214.
- Demitrack MA, Engleberg NC. Chronic fatigue syndrome. Curr Ther Endocrinol Metab. 1994;5:135.
